Table 1. Association (p-value) of SNPs tested by univariate regression or multiple regression with progressive addition of known dose predictorsa.
| Predictors in regression analysis | Tested SNP | ||||
| VKORC1 | CYP2C9*3 | CYP2C9*2 | CYP4F2 | Distribution of all SNPs | |
| rs9923231 | rs1057910 | rs1799853 | rs2108622 | ||
| None | 5.4E-78 | 4.5E-17 | 8.8E-13 | 1.6E-05 | Figure 1A |
| Age, sex | 7.3E-97 | 1.2E-24 | 2.4E-14 | 4.8E-06 | – |
| Age, sex, VKORC1 | – | 3.8E-43 | 1.0E-15 | 4.6E-07 | – |
| Age, sex, VKORC1, CYP2C9*3 | – | – | 1.4E-26 | 8.3E-08 | – |
| Age, Sex, VKORC1, CYP2C9*3 and *2 | – | – | – | 8.3E-10 | Figure 1B |
a
Linear regression on warfarin dose was calculated for the 1,053 GWAS subjects.