Table 2. Multiple regression analysis of warfarin dose in the GWAS, replication and combined panels.
| Predictor | WARG GWAS (1053) | Replication (588) | Combined (1641) | ||||||
| Effect on doseb | R 2 | P-value | Effect on doseb | R 2 | P-value | Effect on doseb | R 2 | P-value | |
| Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | |||||||
| VKORC1 rs9923231 (C->T, 0.402)a | −0.96 (−1.03, −0.89) | 0.283 | 1.6E-122 | −0.99 (−1.09, −0.88) | 0.284 | 5.0E-62 | −0.97 (−1.02, −0.91) | 0.283 | 2.7E-181 |
| CYP2C9*3 rs1057910 (Ile359Leu, 0.070)a | −1.13 (−1.26, −1.00) | 0.075 | 2.6E-55 | −1.08 (−1.27, −0.89) | 0.089 | 2.3E-26 | −1.11 (−1.22, −1.00) | 0.080 | 2.6E-79 |
| CYP2C9*2 rs1799853 (Arg144Cys, 0.109)a | −0.63 (−0.74, −0.52) | 0.048 | 1.7E-28 | −0.40 (−0.55, −0.24) | 0.023 | 5.5E-07 | −0.54 (−0.63, −0.45) | 0.038 | 1.1E-31 |
| CYP4F2 rs2108622 (Val433Met, 0.240)a | 0.25 (0.17, 0.33) | 0.016 | 8.3E-10 | 0.16 (0.05, 0.27) | 0.005 | c0.0029 | 0.21 (0.14, 0.27) | 0.011 | 3.3E-10 |
| Age | −0.04 (−0.04, −0.03) | 0.170 | 1.9E-63 | −0.03 (−0.04, −0.03) | 0.129 | 1.7E-31 | −0.04 (−0.04, −0.03) | 0.155 | 1.2E-111 |
| Sex (male) | 0.35 (0.25, 0.45) | 0.017 | 7.6E-12 | 0.25 (0.10, 0.40) | 0.009 | 0.001 | 0.30 (0.22, 0.38) | 0.013 | 1.6E-12 |
a
In parenthesis are major/minor allele, and minor allele frequency.
b
Effect of individual predictor on dose is indicated by regression coefficient and 95% confidence interval, proportion of explained variance (R 2) and P-value.
c
Association in same direction as GWAS was assessed by a one-tailed test.