Table 3. Power to detect a dose-altering SNP as a function of its contribution to dose variance (R 2) and adjustment by other predictors in the multiple regression modela.
| Predictors adjusted in multiple regression | Tested SNP | ||||||
| VKORC1 | CYP2C9*3 | CYP2C9*2 | CYP4F2 | Unknown | Unknown | ||
| description | total | rs9923231 | rs1057910 | rs1799853 | rs2108622 | SNP of | SNP of |
| R 2 | (R 2 = 0.283) | (R 2 = 0.080) | (R 2 = 0.038) | (R 2 = 0.011) | R 2 = 0.015 | R 2 = 0.010 | |
| None | 0.000 | 1.00 | 1.00 | 0.88 | 0.03 | 0.10 | 0.02 |
| Age, sex | 0.168 | 1.00 | 1.00 | 0.96 | 0.06 | 0.19 | 0.04 |
| Age, sex, VKORC1 | 0.452 | – | 1.00 | 1.00 | 0.26 | 0.56 | 0.19 |
| Age, sex, VKORC1, CYP2C9*3 | 0.532 | – | – | 1.00 | 0.40 | 0.73 | 0.31 |
| Age, Sex, VKORC1, CYP2C9*3 and *2 | 0.570 | – | – | – | 0.48 | 0.81 | 0.39 |
| Age, Sex, VKORC1, CYP2C9*3 and *2, CYP4F2 | 0.580 | – | – | – | – | 0.82 | 0.41 |
a
Power calculations assumed a sample size of 1,053 subjects and significance level of 1.5E-7 as employed in our GWAS.