Figure 3. Relationship between virus population size and genetic drift in a variety of cell cultures.

A. In C8166 cells. B. In CEMx174 cells. C. In 1∶1 mixture of C8166 and CEMx174 cells. D. In PBMCs. Each point corresponds to average variance in frequency of Vpr-FS-StuI from initial 50% (see Materials and Methods). Error bars are 95% confidence intervals. Population size N is defined as the average number of infected cells in each culture at the beginning of the experiment. The expected variance for an ideal population is shown as straight dashed line.