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. Author manuscript; available in PMC: 2009 Mar 9.
Published in final edited form as: Circ Res. 2008 Jul 31;103(5):502–508. doi: 10.1161/CIRCRESAHA.108.177352

Fig. 6.

Fig. 6

Activation and activity of WT-EK and T555I/Q568P-EK corin proteins. A. Schematic illustrations of WT (WT-EK) and T555I/Q568P (I/P-EK) versions of corin that contain an EK recognition sequence (DDDDK) at the conserved activation site. B. Recombinant WT-EK and I/P-EK were activated by increasing concentrations of recombinant EK (rEK), as shown by Western analysis under reducing conditions. C. The activity of EK-activated WT-EK and I/P-EK was tested in pro-ANP processing assays by Western blotting. The data shown were representative of three independent experiments.