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. Author manuscript; available in PMC: 2010 Feb 1.

Published in final edited form as: Brain Behav Immun. 2008 Sep 27;23(2):169–175. doi: 10.1016/j.bbi.2008.09.011

Fig. 1 — A/C, WAT was collected from hypoxic exposed C57BL/6J mice at the times indicated (−2 h = prior to hypoxia, 0 = immediately post hypoxia, 2 h = 2 h post hypoxia). Leptin (A) and IL-1RA (C) were measured in WAT tissue homogenates by ELISA. B/D, C57BL/6J mice were treated as in A/C and serum collected. Leptin (B) and IL-1RA (D) were measured by ELISA. Results are expressed as means ± SEM; n = 4/time point; *p < 0.05 vs −2 h. E, Macrophages were treated with or without leptin (620 nM) and/or normoxia or hypoxia for 2 h as indicated. Results are expressed as means ± SEM; n = 4; *p < 0.05 leptin vs phosphate buffered saline (PBS) (normoxia and hypoxia), # p < 0.05 normoxia vs hypoxia (PBS and leptin.), $ p <0.05 leptin normoxia vs PBS hypoxia.

Fig. 1 — A/C, WAT was collected from hypoxic exposed C57BL/6J mice at the times indicated (−2 h = prior to hypoxia, 0 = immediately post hypoxia, 2 h = 2 h post hypoxia). Leptin (A) and IL-1RA (C) were measured in WAT tissue homogenates by ELISA. B/D, C57BL/6J mice were treated as in A/C and serum collected. Leptin (B) and IL-1RA (D) were measured by ELISA. Results are expressed as means ± SEM; n = 4/time point; *p < 0.05 vs −2 h. E, Macrophages were treated with or without leptin (620 nM) and/or normoxia or hypoxia for 2 h as indicated. Results are expressed as means ± SEM; n = 4; *p < 0.05 leptin vs phosphate buffered saline (PBS) (normoxia and hypoxia), # p < 0.05 normoxia vs hypoxia (PBS and leptin.), $ p <0.05 leptin normoxia vs PBS hypoxia.