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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Fertil Steril. 2008 Jan 28;90(6):2060–2067. doi: 10.1016/j.fertnstert.2007.10.070

Table 2.

Absolute and percent change in bone mineral density (BMD) at L1-L4 spine and femoral neck. DMPA=depot medroxyprogesterone acetate, OC=oral contraceptive (20 mcg ethinyl estradiol + 0.1mg levonorgestrel).

Endpoint Time Adjusted Group Mean(SE)*
P-Values
Untreated DMPA OC
Spine-Absolute 0 0.98(0.007) 0.97(0.013) 1.01(0.007)
Values g/cm2 6 1.00(0.007) 0.96(0.013) 1.02(0.007) DMPA vs. OC (p=.005)
12 1.02(0.008) 0.95(0.013) 1.03(0.008) DMPA vs. OC (p<.001), DMPA vs. Control (p=.003)
18 1.03(0.008) 0.95(0.013) 1.03(0.008) DMPA vs. OC (p<.001), DMPA vs. Control (p<.001)
24 1.04(0.008) 0.94(0.014) 1.03(0.008) DMPA vs. OC (p<.001), DMPA vs. Control (p<.001)
Significant Increase in Controls (p<.001)
Significant Increase in OCs (p<.001)
Spine-%Change (0–24 mos.) - 6.3% (0.53%) −1.5% (1.01%) 4.2% (0.70%) DMPA vs. OC (p<.001), DMPA vs. Control (p<.001),
Femoral Neck-Absolute Values g/cm2 0 0.92(0.010) 0.92(0.017) 0.96(0.010)
6 0.93(0.010) 0.90(0.017) 0.96(0.010)
12 0.94(0.011) 0.90(0.018) 0.96(0.011)
18 0.95(0.011) 0.86(0.019) 0.97(0.011) DMPA vs. OC (p<.001)
24 0.96(0.012) 0.86(0.020) 0.97(0.012) DMPA vs. OC (p<.001), DMPA vs. Control (p=.003)
Significant Increase in Controls (p=.006)
Significant Decrease in DMPAs (p<.001)
Femoral Neck-%Change (0–24 mos.) - 3.8% (0.80%) −5.2% (1.57%) 3.0% (1.02%) DMPA vs. OC (p<.001), DMPA vs. Control (p<.001)
*

Values adjusted for age, race, body weight, tobacco use, physical activity and baseline BMD.