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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Ann Hum Genet. 2008 Jul 3;72(Pt 4):443–453. doi: 10.1111/j.1469-1809.2008.00433.x

Figure 1.

Figure 1

Scheme for the stepwise analysis of association. Dataset size and the number of SNPs tested in each step are indicated. In the initial dataset, tagSNPs were examined in the old affecteds and left main cases separately. Stronger associations were found in the left main cases. Promising SNPs that displayed evidence for association (p<0.1) with left main CAD were further analyzed in the validation dataset composed of left main cases and controls only. Joint analysis was performed on the initial and validation datasets to maximize statistical power in evaluating association with left main CAD. Significant SNPs from the joint analysis (p<0.05) were then further validated in the third control dataset and family-based GENECARD samples.