Table 2.
Results of human SLC34A2 allelic association tests in Phase II
| SLC | SBP | DBP | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HWE | Unadjusted | Adjusted | Unadjusted | Adjusted | Unadjusted | Adjusted | |||
| SNP | Position | MAF | P | P | P* | P | P* | P | P* |
| rs12501856 | Intron 1 | 0.34 | 0.79 | 0.04 | 0.02 | 0.37 | 0.19 | 0.35 | 0.79 |
| rs3775909 | Intron 3 | 0.18 | 0.66 | 0.78 | 0.83 | 0.34 | 0.32 | 0.96 | 0.26 |
| rs3796777 | Intron 9 | 0.13 | 0.38 | 0.68 | 0.58 | 0.33 | 0.34 | 0.33 | 0.86 |
| rs2240995 | Intron 10 | 0.18 | 0.99 | 0.91 | 0.93 | 0.37 | 0.32 | 0.8 | 0.82 |
| rs2240996 | Intron 10 | 0.12 | 0.38 | 0.92 | 0.62 | 0.96 | 0.56 | 0.037 | 0.07 |
| rs12505556 | Intron 12 | 0.13 | 0.98 | 0.64 | 0.62 | 0.51 | 0.75 | 0.038 | 0.05 |
| rs6448389 | Exon13 | 0.13 | 0.27 | 0.12 | 0.39 | 0.98 | 0.44 | 0.52 | 0.74 |
SNP indicates single-nucleotide polymorphism; MAF, minor allele frequency; HWE, hardy-weinberg equilibrium; SLC, sodium lithium countertransport; SBP, systolic blood pressure; and DBP, diastolic blood pressure.
*
P value is adjusted by age, sex and body mass index.
The significance level for a single test is set as p=0.007 (α = 0.05/7; Seven SNPs).