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The mode of action of gp41e inhibition of fusion protein clustering. The exogenous gp41e trimer (green) interferes with Env recruitment. The resulting Env-gp41e complex blocks the formation of a functional pore and the progress to complete fusion because gp41e lacks a TMD and cytoplasmic tail needed for the disruption of inner leaflets of fusing membranes. This could be a mechanism of fusion inhibition by gp41e.
