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. Author manuscript; available in PMC: 2009 Mar 9.
Published in final edited form as: J Biomol Screen. 2008 Jan 23;13(2):120–127. doi: 10.1177/1087057107313786

Fig. 6. Dose response curves and structures of four representative TSH receptor agonists.

Fig. 6

Activities of compounds were normalized to the maximal response of TSH (30 nM) and the DMSO control in the TSH receptor cell line (closed circles) and the parental cell line (open triangles). All four compounds were inactive in the parental cell line (without the TSH receptor). (a) NCGC00057417 with an EC50 of 2.15 µM and 69.8% maximal response at 10 µM concentration. (b) NCGC00038940 with an EC50 of 2.57 µM and 46.6 % maximal response at 10 µM concentration. (c) NCGC00054245 with an EC50 of 10.1 µM and 50.6 % maximal response at 10 µM concentration. (d) NCGC00026086 with an EC50 of 1.70 µM and 54.5 % maximal response at 10 µM concentration.