Table 1.

Critical motors for transport of presynaptic organelles

Kinesin family	Axonal motor	Phenotypes of motor loss/disruption	Associated neuronal proteins
		Severe reduction of mitochondrial flux and number in axons [34]	Milton [35,•36]
			KLC [7]
	C. elegans UNC-116
Kinesin-1	D. melanogastor KHC	Mislocalized accumulations of SVs and mitochondria in axons [7]	Syntabulin [31]
			Liprin-α [27]
	Mammalian KIF5A KIF5B KIF5C	Reduced synapse formation and function [7]	RanBP2 [41]
			SNAP-25, SNAP-23 [60]
			Calsyntenin [61]
		Reduced neurite outgrowth [7]	β-dystrobrevin [62]
	C. elegans UNC-104	SVs stranded in cell body and severely reduced at synapse [7]
	D. melanogastor Imac	Decrease in synapse number [7]	Liprin-α[63]
Kinesin-3
	Mammalian KIF1A KIF1Bα KIF1Bβ KIF1C	Failed development of morphological synapse [••9]	KBP [42]
		Decrease in mitochondria motility [7]