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Top1-deficient P388/CPT45 cells are resistant to ara-C. (A) Top1 content of P388 and P388/CPT45 cells were analyzed by Western blotting using the C21 human top1 mAb. Lanes 1, 105 cells; lanes 2, 2 × 105 cells. Numbers on the right indicate the migration position of molecular mass markers. (B) Growth inhibition in P388 (○) and P388/CPT45 cells (●) was measured by MTT assay after continuous treatment with ara-C for 3 and 5 days, respectively.
