Table 1.
Mineralized Tissue Cell Types and their Cell Specifica Protein Markers
| Cell | Marker | Also Used as Markersb |
|---|---|---|
| Hypertrophic Chondrocyte | Type X collagen 257 | Types II and IX collagen |
| MMP-9 258 | DMP1 | |
| Osteoblast | Osteocalcin259 | Type I collagen |
| Periostin 260 | Alkaline phosphatase | |
| Bone sialoprotein (BSP) 261 | Runx2 264,265 | |
| MEPE/OF45 262 | Osterix 266 | |
| PHEX/Pex 263 | Response to PTH 267 | |
| Osteocyte | Sclerostin (SOST) 268,269 | Osteocalcin |
| DMP1 19,270 | Type I collagen | |
| Actin-binding proteins 271 | Alkaline phosphatase | |
| Fimbrin 271 | ||
| Podoplanin/E11 21 | ||
| MEPE/OF45 262 | ||
| PHEX/Pex 272 | ||
| Odontoblast | Dspp (gene) 156,273,274 | Type I collagen |
| -Phosphophoryn 156 | Alkaline Phosphotase 276 | |
| -Dentin sialoprotein 156,274 | MEPE 276 | |
| DMP4 275 | ||
| Cementoblast | Cementum protein 23 277 | Bone matrix proteins |
| Ameloblast | Amelogenin 207 | |
| Ameloblastin 207,278 | ||
| Tuftelin 279 | ||
| Enamelin 280 | ||
| Amelotin 281 | ||
| Cytokeratin 14 282 |
a
Some of these proteins are found at low levels in other tissues
b
Many of the protein markers listed here are expressed at high levels by two or more of these cell types but are frequently designated as markers