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. 2008 Oct 1;26(28):4659–4665. doi: 10.1200/JCO.2008.16.9235

Table 4.

Pharmacokinetic Parameters for STI571 and its Main Metabolite, CGP74588, in Patients Not Taking Antiepileptic Drugs and Patients Taking Either EIAEDs or Non-EIAEDs

Parameter No. Median Minimum Observed Value Maximum Observed Value P (df = 2) All Patients
Cmax, STI571, ng/mL
    No antiepileptic drugs 18 1595 533 3930 .0019
    EIAEDs 37 861 35 2960
    Non-EIAEDs 25 1270 78 4620
Cmax, CGP74588, ng/mL
    No antiepileptic drugs 18 225 49 1170 .35
    EIAEDs 37 198 18 892
    Non-EIAEDs 25 166 11 570
AUC, STI571, ng·h/mL
    No antiepileptic drugs 18 1263 314 2574 < .0001
    EIAEDs 37 614 247 1611
    Non-EIAEDs 25 1139 192 3021
AUC, CGP74588, ng·h/mL
    No antiepileptic drugs 18 174 34 942 .31
    EIAEDs 37 152 59 529
    Non-EIAEDs 25 160 22 552
RAP29, STI571
    No antiepileptic drugs 10 1.87 0.68 16.44 .99
    EIAEDs 28 1.85 0.62 6.58
    Non-EIAEDs 15 1.80 0.88 24.38
RAP29, CGP74588
    No antiepileptic drugs 10 2.75 1.48 9.70 .87
    EIAEDs 28 2.65 1.23 6.46
    Non-EIAEDs 15 2.25 0.92 39.60

Abbreviations: EIAEDs, enzyme-inducing antiepileptic drugs; Non-EIAEDs, non–enzyme-inducing AEDs; Cmax, maximum concentration; AUC, area under the curve; RAP, concentration at steady state (day 29 before taking imatinib).