Table 4.
Parameter | No. | Median | Minimum Observed Value | Maximum Observed Value | P (df = 2) All Patients |
---|---|---|---|---|---|
Cmax, STI571, ng/mL | |||||
No antiepileptic drugs | 18 | 1595 | 533 | 3930 | .0019 |
EIAEDs | 37 | 861 | 35 | 2960 | |
Non-EIAEDs | 25 | 1270 | 78 | 4620 | |
Cmax, CGP74588, ng/mL | |||||
No antiepileptic drugs | 18 | 225 | 49 | 1170 | .35 |
EIAEDs | 37 | 198 | 18 | 892 | |
Non-EIAEDs | 25 | 166 | 11 | 570 | |
AUC, STI571, ng·h/mL | |||||
No antiepileptic drugs | 18 | 1263 | 314 | 2574 | < .0001 |
EIAEDs | 37 | 614 | 247 | 1611 | |
Non-EIAEDs | 25 | 1139 | 192 | 3021 | |
AUC, CGP74588, ng·h/mL | |||||
No antiepileptic drugs | 18 | 174 | 34 | 942 | .31 |
EIAEDs | 37 | 152 | 59 | 529 | |
Non-EIAEDs | 25 | 160 | 22 | 552 | |
RAP29, STI571 | |||||
No antiepileptic drugs | 10 | 1.87 | 0.68 | 16.44 | .99 |
EIAEDs | 28 | 1.85 | 0.62 | 6.58 | |
Non-EIAEDs | 15 | 1.80 | 0.88 | 24.38 | |
RAP29, CGP74588 | |||||
No antiepileptic drugs | 10 | 2.75 | 1.48 | 9.70 | .87 |
EIAEDs | 28 | 2.65 | 1.23 | 6.46 | |
Non-EIAEDs | 15 | 2.25 | 0.92 | 39.60 |
Abbreviations: EIAEDs, enzyme-inducing antiepileptic drugs; Non-EIAEDs, non–enzyme-inducing AEDs; Cmax, maximum concentration; AUC, area under the curve; RAP, concentration at steady state (day 29 before taking imatinib).