Table 2.
Overall Survival of the Two Arms and Historical Control
| Measure | Fluorouracil-Based Arm
|
Non–Fluorouracil-Based Arm
|
RTOG 9405 Arm 2
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Alive | 95% CI (%) | Cumulative Deaths (No.) | No. of Patients at Risk | % Alive | 95% CI (%) | Cumulative Deaths (No.) | No. of Patients at Risk | % Alive | 95% CI (%) | Cumulative Deaths (No.) | No. of Patients at Risk | |
| Months | ||||||||||||
| 0 | 100.0 | 0 | 37 | 100.0 | 0 | 35 | 100.0 | 0 | 109 | |||
| 6 | 91.9 | 76.9 to 97.3 | 3 | 34 | 91.4 | 75.7 to 97.2 | 3 | 32 | 84.4 | 76.1 to 90.0 | 17 | 92 |
| 12 | 75.7 | 58.5 to 86.5 | 9 | 28 | 68.6 | 50.5 to 81.2 | 12 | 24 | 66.0 | 56.3 to 74.1 | 37 | 71 |
| 18 | 64.9 | 47.3 to 77.9 | 13 | 24 | 40.0 | 24.0 to 55.5 | 22 | 14 | 52.0 | 42.2 to 60.9 | 52 | 55 |
| 24 | 55.9 | 38.4 to 70.3 | 15 | 18 | 36.9 | 21.4 to 52.5 | 24 | 12 | 41.6 | 32.2 to 50.7 | 63 | 43 |
| Total deaths | 21 | 27 | 78 | |||||||||
| Median survival time, months | 28.7 | 14.9 | 18.8 | |||||||||
| 95% CI | 17.7 to NC | 12.1 to 26.4 | 15.4 to 25.1 | |||||||||
| P* | .1038 | .1648 | ||||||||||
Abbreviations: RTOG, Radiation Therapy Oncology Group; NC, not calculable.
*
Treatment comparisons versus RTOG 9405 arm 2 historical control (one-sided log-rank test).