Table 3.
Chemotherapy and Acute Radiotherapy Toxicity
| Toxicity | Fluorouracil-Based Arm (n = 37)Grade (No. of patients)
|
Non–Fluorouracil-Based Arm (n = 35)Grade (No. of patients)
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 1 | 2 | 3 | 4 | 5 | |
| Allergy/immunology | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Auditory/hearing | 1 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| Blood/bone marrow | 4 | 17 | 5 | 9 | 0 | 5 | 5 | 14 | 10 | 0 |
| Cardiovascular, arrhythmia | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
| Cardiovascular, general | 2 | 3 | 4 | 2 | 0 | 4 | 3 | 2 | 1 | 0 |
| Constitutional symptoms | 10 | 12 | 9 | 0 | 0 | 6 | 16 | 6 | 3 | 0 |
| Dermatology/skin | 9 | 17 | 1 | 0 | 0 | 5 | 14 | 0 | 0 | 0 |
| GI | 5 | 12 | 18 | 2 | 0 | 4 | 8 | 15 | 6 | 0 |
| Hemorrhage | 1 | 0 | 1 | 0 | 1 | 5 | 0 | 0 | 0 | 0 |
| Hepatic | 8 | 1 | 2 | 0 | 0 | 5 | 5 | 0 | 1 | 0 |
| Infection/febrile neutropenia | 0 | 1 | 8 | 0 | 0 | 2 | 4 | 5 | 0 | 1 |
| Lymphatics | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Metabolic/laboratory | 8 | 7 | 5 | 2 | 0 | 5 | 2 | 8 | 1 | 0 |
| Musculoskeletal | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
| Neurology | 7 | 4 | 4 | 0 | 0 | 10 | 4 | 4 | 0 | 0 |
| Ocular/visual | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| Pain | 12 | 6 | 1 | 0 | 0 | 5 | 8 | 4 | 0 | 0 |
| Pulmonary | 4 | 6 | 1 | 0 | 0 | 2 | 3 | 1 | 0 | 0 |
| Renal/genitourinary | 5 | 2 | 0 | 0 | 0 | 4 | 3 | 0 | 0 | 0 |
| Worst nonhematologic | 1 | 6 | 25 | 4 | 1 | 1 | 8 | 17 | 8 | 1 |
| % of patients | 3 | 16 | 68 | 11 | 3 | 3 | 23 | 49 | 23 | 3 |
| Worst overall | 0 | 6 | 20 | 10 | 1 | 0 | 5 | 15 | 14 | 1 |
| % of patients | 0 | 16 | 54 | 27 | 3 | 0 | 14 | 43 | 40 | 3 |