Table 3.
Toxicity | Fluorouracil-Based Arm (n = 37)Grade (No. of patients)
|
Non–Fluorouracil-Based Arm (n = 35)Grade (No. of patients)
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 1 | 2 | 3 | 4 | 5 | |
Allergy/immunology | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Auditory/hearing | 1 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
Blood/bone marrow | 4 | 17 | 5 | 9 | 0 | 5 | 5 | 14 | 10 | 0 |
Cardiovascular, arrhythmia | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Cardiovascular, general | 2 | 3 | 4 | 2 | 0 | 4 | 3 | 2 | 1 | 0 |
Constitutional symptoms | 10 | 12 | 9 | 0 | 0 | 6 | 16 | 6 | 3 | 0 |
Dermatology/skin | 9 | 17 | 1 | 0 | 0 | 5 | 14 | 0 | 0 | 0 |
GI | 5 | 12 | 18 | 2 | 0 | 4 | 8 | 15 | 6 | 0 |
Hemorrhage | 1 | 0 | 1 | 0 | 1 | 5 | 0 | 0 | 0 | 0 |
Hepatic | 8 | 1 | 2 | 0 | 0 | 5 | 5 | 0 | 1 | 0 |
Infection/febrile neutropenia | 0 | 1 | 8 | 0 | 0 | 2 | 4 | 5 | 0 | 1 |
Lymphatics | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Metabolic/laboratory | 8 | 7 | 5 | 2 | 0 | 5 | 2 | 8 | 1 | 0 |
Musculoskeletal | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Neurology | 7 | 4 | 4 | 0 | 0 | 10 | 4 | 4 | 0 | 0 |
Ocular/visual | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
Pain | 12 | 6 | 1 | 0 | 0 | 5 | 8 | 4 | 0 | 0 |
Pulmonary | 4 | 6 | 1 | 0 | 0 | 2 | 3 | 1 | 0 | 0 |
Renal/genitourinary | 5 | 2 | 0 | 0 | 0 | 4 | 3 | 0 | 0 | 0 |
Worst nonhematologic | 1 | 6 | 25 | 4 | 1 | 1 | 8 | 17 | 8 | 1 |
% of patients | 3 | 16 | 68 | 11 | 3 | 3 | 23 | 49 | 23 | 3 |
Worst overall | 0 | 6 | 20 | 10 | 1 | 0 | 5 | 15 | 14 | 1 |
% of patients | 0 | 16 | 54 | 27 | 3 | 0 | 14 | 43 | 40 | 3 |