Table A2.
Cancers of Participants and First- and Second-Degree Relatives, by Race and BRCA1/2 Mutation Status
| Characteristic | Asian (n = 200)
|
White (n = 200)
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
BRCA1 (n = 23)
|
BRCA2 (n = 26)
|
None* (n = 151)
|
Total (n = 200)
|
BRCA1 (n = 15)
|
BRCA2 (n = 11)
|
None* (n = 175)
|
Total (n = 200)
|
|||||||||
| No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | |
| Personal cancer history | ||||||||||||||||
| None | 0 | 0 | 1 | 3.8 | 8 | 5.3 | 9 | 4.5 | 0 | 0 | 0 | 0 | 29 | 16.6 | 29 | 14.5 |
| Unilateral breast | 12 | 52.2 | 13 | 50 | 106 | 71 | 131 | 65.5 | 7 | 46.7 | 4 | 36.4 | 110 | 62.9 | 121 | 60.5 |
| Bilateral breast | 2 | 8.7 | 7 | 26.9 | 12 | 7.9 | 21 | 10.5 | 1 | 6.7 | 1 | 9.1 | 11 | 6.3 | 13 | 6.5 |
| Ovarian | 8 | 34.8 | 3 | 11.5 | 10 | 6.6 | 21 | 10.5 | 3 | 20 | 2 | 18.2 | 11 | 6.3 | 16 | 8 |
| DCIS† | 2 | 8.7 | 4 | 15.4 | 52 | 34.4 | 58 | 29 | 2 | 13.3 | 3 | 27.3 | 52 | 29.7 | 57 | 28.5 |
| Breast and ovarian | 1 | 4.4 | 0 | 0 | 9 | 6 | 10 | 5 | 2 | 13.3 | 3 | 27.3 | 2 | 1.1 | 7 | 3.5 |
| Other cancer | 2‡ | 8.7 | 0 | 0 | 8§ | 5.3 | 10 | 5 | 1‖ | 6.7 | 2¶ | 18.2 | 8# | 4.6 | 11 | 5.5 |
| Proband's age at cancer onset | ||||||||||||||||
| Breast | ||||||||||||||||
| Median | 39 | 37.5 | 44 | 43 | 42 | 43 | 45 | 44 | ||||||||
| Range | 32-61 | 27-55 | 23-77 | 23-77 | 33-73 | 38-66 | 29-69 | 29-73 | ||||||||
| Ovarian | ||||||||||||||||
| Median | 47 | 54 | 49 | 49 | 44 | 51 | 55 | 51 | ||||||||
| Range | 39-54 | 45-55 | 28-74 | 28-74 | 36-58 | 48-70 | 37-77 | 36-77 | ||||||||
| Family cancer history | ||||||||||||||||
| No breast or ovarian | 7 | 30.4 | 3 | 11.5 | 40 | 26.5 | 50 | 25 | 0 | 0 | 2 | 18.2 | 27 | 15.4 | 29 | 14.5 |
| Breast only | 6 | 26.1 | 19 | 73.1 | 92 | 60.9 | 117 | 58.5 | 7 | 46.7 | 7 | 63.6 | 113 | 64.6 | 127 | 63.5 |
| Ovarian only | 3 | 13 | 4 | 15.4 | 12 | 7.9 | 19 | 9.5 | 2 | 13.3 | 0 | 0 | 15 | 8.6 | 17 | 8.5 |
| Breast and ovarian | 7 | 30.4 | 0 | 0 | 7 | 4.6 | 14 | 7 | 6 | 40 | 2 | 18.2 | 20 | 11.4 | 27 | 13.5 |
| No. of cancers in relatives | ||||||||||||||||
| No. of relatives recorded | ||||||||||||||||
| Median | 21 | 17.5 | 19 | 19 | 15 | 15 | 15 | 15 | ||||||||
| Range | 5-47 | 6-42 | 6-56 | 5-56 | 9-33 | 10-25 | 5-56 | 5-56 | ||||||||
| Relatives with breast cancer | ||||||||||||||||
| Median | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| Range | 0-2 | 0-4 | 0-4 | 0-4 | 0-4 | 0-4 | 0-5 | 0-5 | ||||||||
| Relatives with ovarian cancer | ||||||||||||||||
| Median | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||||
| Range | 0-3 | 0-2 | 0-3 | 0-3 | 0-2 | 0-1 | 0-2 | 0-2 | ||||||||
*
Includes patients with BRCA1/2 variants of uncertain significance.
†
Ductal carcinoma-in-situ, occurring most often in patients who also had invasive breast cancer.
‡
Bladder, endometrial.
§
Cervical (n = 2), vaginal, colon (n = 2), endometrial (n = 2), non-Hodgkin's lymphoma, ossifying fibromyxoid tumor, and bladder.
‖
Melanoma.
¶
Non-Hodgkin's lymphoma, basal cell carcinoma.
#
Melanoma (n = 2), basal cell, laryngeal, hemangiopericytoma, endometrial, unknown (n = 2).