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. Author manuscript; available in PMC: 2009 Nov 21.
Published in final edited form as: J Org Chem. 2008 Oct 21;73(22):9027–9032. doi: 10.1021/jo8018895

Scheme 1.

Scheme 1

Formation of indazole oxides by tandem reaction

Reagents and conditions: (i) traditional Fmoc peptide synthesis; (ii) 2,4-dinitrobenzenesulfonyl chloride, lutidine, DCM, 16h; (iii) 2-bromo-4′-methyl-acetophenone, DIEA, DMF, 16h; (iv) DBU, DMF, 30 min; (v) 50% TFA in DCM, 30 min.