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Preparation of five types of resin-bound amines
Reagents and conditions: (i) Fmoc-amino acid, DIC, HOBt, DMF/DCM, 16h; (ii) 50% piperidine, DMF, 15 min; (iii) amine, 10% AcOH, DMF, 16h, then NaBH(OAc)3, 5h; (iv) Fmoc-amino acid, PPh3, DIAD, 3h; (v) CDI, pyridine, DCM, 2h, then diamine, DCM, 2h; (vi) trichloroacetonitrile, DBU, DCM, 2h, then Fmoc-amino alcohol, BF3•Et2O, 1h.
