TABLE 1.
Details of the 43 C. albicans isolates included in this study
| Isolate | MLST data
|
Source countryb | Sample or anatomical source | ABC type | MAT type | Inoculation details
|
Survival time (days)
|
Kidney log CFU/g (mean ± SD) | % wt change from day 0 to 3 (mean ± SD) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clade | DSTa | 104 CFU/g (mean ± SD) | No. of repetitionsc | Median | Mean ± SD | |||||||
| YsU751d | 1 | 69 | Malaysia | Urine | A | a/α | 2.5 ± 0.9 | 3 | 8.0 | 7.3 ± 4.1 | 7.5 ± 0.3 | −10.3 ± 9.6 |
| HUN92 | 1 | 37 | UK | Blood | A | a/α | 2.1 ± 0.7 | 3 | 28.0 | 23.0 ± 7.8 | 4.1 ± 1.9 | −2.0 ± 4.9 |
| FJ9 | 1 | 102 | Fiji | Oropharynx | A | a/α | 2.4 ± 1.3 | 3 | 15.5 | 16.5 ± 5.5 | 7.1 ± 1.3 | −6.0 ± 4.8 |
| RIHO9d | 1 | 100 | USA | Blood | A | a/a | 2.3 ± 1.3 | 3 | 28.0 | 25.5 ± 4.5 | 5.3 ± 1.2 | 2.6 ± 3.1 |
| 78/028 | 1 | 73 | UK | Oropharynx | A | a/α | 1.9 ± 0.3 | 3 | 28.0 | 28.0 ± 0.0 | 3.3 ± 1.4 | 3.2 ± 3.4 |
| AM2002/0087d | 1 | 135 | UK | Blood | A | a/α | 2.4 ± 0.9 | 3 | 12.0 | 13.2 ± 8.4 | 7.3 ± 0.5 | −11.7 ± 6.9 |
| HUN96 | 1 | 116 | UK | Blood | A | a/α | 2.0 ± 0.3 | 3 | 28.0 | 28.0 ± 0.0 | 4.0 ± 2.2 | 1.7 ± 3.6 |
| AM2003-013 | 1 | 120 | UK | Oropharynx | A | a/α | 2.3 ± 0.9 | 3 | 11.5 | 13.7 ± 8.0 | 6.4 ± 1.4 | −5.2 ± 6.4 |
| AM2003-016 | 1 | 123 | UK | Oropharynx | A | a/α | 1.8 ± 0.5 | 3 | 28.0 | 24.3 ± 9.0 | 5.4 ± 1.0 | −2.8 ± 2.5 |
| J981301 | 1 | 60 | USA | Vagina | A | a/α | 2.0 ± 0.7 | 3 | 28.0 | 27.2 ± 2.0 | 6.7 ± 1.5 | −0.7 ± 4.4 |
| 81/064d | 1 | 129 | UK | Vagina | A | α/α | 1.3 ± 0.2 | 3 | 28.0 | 24.8 ± 6.0 | 4.2 ± 2.4 | 2.1 ± 4.5 |
| J981318 | 1 | 86 | USA | Vagina | A | a/α | 1.9 ± 0.4 | 3 | 6.5 | 6.7 ± 1.6 | 6.6 ± 0.3 | −13.2 ± 4.6 |
| J951361 | 1 | 44 | UK | Blood | A | a/α | 2.1 ± 0.2 | 2 | 5.0 | 5.3 ± 1.6 | 6.1 ± 1.6 | −15.1 ± 4.6 |
| SC5314d | 1 | 52 | USA | Blood | A | a/α | 1.8 ± 0.3 | 3 | 7.5 | 6.8 ± 1.6 | 6.0 ± 1.0 | −15.7 ± 2.2 |
| AM2003/0089 | 2 | 155 | UK | Blood | A | a/α | 1.5 ± 0.3 | 2 | 11.0 | 16.0 ± 9.4 | 4.9 ± 2.7 | −1.4 ± 4.6 |
| IHEM16972 | 2 | 155 | Rwanda | Oropharynx | A | a/α | 2.7 ± 0.8 | 2 | 9.5 | 12.2 ± 8.0 | 6.3 ± 0.9 | −5.3 ± 4.6 |
| FC22 | 2 | 155 | USA | Vagina | A | a/α | 2.3 ± 0.2 | 2 | 12.5 | 13.8 ± 5.6 | 7.0 ± 0.8 | −2.4 ± 3.1 |
| IHEM16614d | 2 | 206 | Rwanda | Oropharynx | A | a/α | 2.6 ± 0.6 | 2 | 7.0 | 7.3 ± 1.4 | 6.4 ± 0.6 | −9.9 ± 3.3 |
| AM2003/0100d | 2 | 206 | UK | Blood | A | a/α | 1.5 ± 0.7 | 2 | 28.0 | 20.7 ± 11.4 | 5.9 ± 1.1 | −2.6 ± 5.0 |
| IHEM16945d | 2 | 356 | Rwanda | Oropharynx | A | α/α | 1.8 ± 0.5 | 2 | 13.0 | 14.8 ± 6.8 | 6.1 ± 0.9 | −2.1 ± 4.3 |
| AM2004/0028 | 2 | 326 | UK | Oropharynx | A | a/α | 2.7 ± 0.6 | 2 | 22.0 | 20.3 ± 8.1 | 6.1 ± 1.7 | −0.4 ± 2.9 |
| AM2003/0182 | 2 | 225 | UK | Blood | A | a/α | 2.3 ± 0.8 | 2 | 22.0 | 22.0 ± 5.4 | 6.6 ± 0.9 | −0.3 ± 3.5 |
| AM2003/0191d | 2 | 232 | UK | Blood | A | a/α | 2.5 ± 0.1 | 2 | 8.5 | 10.7 ± 5.9 | 6.5 ± 1.2 | −9.1 ± 5.7 |
| AM2003/0069d | 2 | 194 | UK | Vagina | A | a/α | 2.5 ± 0.8 | 2 | 26.0 | 24.5 ± 4.2 | 4.9 ± 1.7 | 0.7−3.2 |
| FC28d | 3 | 159 | USA | Vagina | B | α/α | 2.4 ± 0.8 | 3 | 28.0 | 26.3 ± 4.1 | 4.1 ± 1.8 | 1.1 ± 4.3 |
| 73/025 | 3 | 132 | UK | Vagina | B | a/α | 2.4 ± 0.0 | 2 | 13.0 | 14.0 ± 6.5 | 6.9 ± 0.7 | −3.2 ± 3.3 |
| J981315 | 3 | 56 | USA | Vagina | B | a/α | 2.0 ± 0.1 | 2 | 10.0 | 13.7 ± 8.0 | 5.7 ± 1.7 | −3.4 ± 5.5 |
| b30708/5d | 3 | 186 | UK | Blood | B | a/α | 3.2 ± 0.9 | 2 | 8.0 | 12.8 ± 8.8 | 5.6 ± 0.9 | 3.3 ± 3.3 |
| T101d | 3 | 236 | Canada | Oropharynx | B | a/a | 2.7 ± 0.8 | 2 | 13.5 | 13.7 ± 3.3 | 6.3 ± 1.0 | −2.6 ± 2.6 |
| J990102d | 3 | 45 | Belgium | Vagina | B | a/α | 2.5 ± 0.1 | 2 | 7.0 | 6.5 ± 0.8 | 7.1 ± 0.3 | −10.3 ± 4.3 |
| AM2003/0074 | 3 | 198 | UK | Blood | B | a/α | 2.1 ± 0.0 | 2 | 28.0 | 27.3 ± 1.6 | 6.0 ± 1.2 | 1.1 ± 5.0 |
| AM2003/0165d | 3 | 332 | UK | Blood | B | α/α | 1.5 ± 0.4 | 2 | 26.5 | 21.7 ± 9.0 | 4.2 ± 2.2 | 0.2 ± 6.0 |
| s20152.082 | 4 | 168 | USA | Blood | C | a/α | 2.6 ± 0.9 | 3 | 14.5 | 14.7 ± 5.5 | 7.2 ± 0.4 | −8.0 ± 9.8 |
| s20152.013 | 4 | 167 | USA | Blood | A | a/α | 2.3 ± 0.3 | 3 | 20.0 | 19.3 ± 9.5 | 6.1 ± 1.6 | −10.7 ± 7.7 |
| AM2005/0377d | 4 | 635 | South Africa | Blood | B | a/a | 2.0 ± 0.0 | 2 | 28.0 | 28.0 ± 0.0 | 5.7 ± 0.7 | 2.4 ± 3.5 |
| s20176.079 | 4 | 164 | USA | Blood | A | a/α | 1.8 ± 0.3 | 3 | 21.0 | 20.7 ± 7.5 | 6.0 ± 1.5 | −0.8 ± 8.5 |
| RV4688d | 4 | 87 | Zaire | Blood | C | a/α | 3.3 ± 0.2 | 3 | 28.0 | 28.0 ± 0.0 | 5.3 ± 2.1 | −0.3 ± 3.6 |
| HUN68 | 4 | 95 | UK | Oropharynx | B | a/α | 1.8 ± 0.6 | 3 | 28.0 | 23.2 ± 7.5 | 6.1 ± 1.4 | 0.8 ± 3.6 |
| s20122.073 | 4 | 95 | Switzerland | Blood | B | a/α | 1.8 ± 0.4 | 3 | 5.0 | 12.5 ± 12.0 | 6.0 ± 1.8 | −8.6 ± 11.1 |
| L1086 | 4 | 144 | Saudi Arabia | Wound | B | a/α | 2.9 ± 0.6 | 3 | 10.0 | 10.7 ± 3.1 | 7.3 ± 0.4 | −7.3 ± 5.5 |
| IHEM3742d | 4 | 124 | Zaire | Blood | C | a/α | 1.9 ± 0.4 | 3 | 28.0 | 28.0 ± 0.0 | 5.1 ± 2.2 | 1.8 ± 3.6 |
| s20175.016d | 4 | 124 | Israel | Blood | C | a/α | 2.3 ± 0.1 | 3 | 28.0 | 26.2 ± 3.0 | 6.9 ± 1.2 | −7.0 ± 5.9 |
| AM2003-020d | 4 | 124 | UK | Oropharynx | C | a/α | 2.8 ± 0.6 | 3 | 12.0 | 13.2 ± 8.9 | 7.1 ± 0.8 | −9.9 ± 4.4 |
a
DST, diploid sequence type.
b
UK, United Kingdom; USA, United States of America.
c
The isolate was tested in two groups of three mice (shown as 2) or tested in three groups of two mice (shown as 3).
d
These isolates were used for expression profiling experiments.