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. 2009 Jan 16;8(3):373–387. doi: 10.1128/EC.00387-08

TABLE 4.

Virulence of 43 C. albicans isolates in mice and other measured characteristics of the isolates tested in vitro

Isolatea Virulence rank by:
Sum of virulence ranks Strain characters
Growth rate [μmax (h−1)] in RPMI 1640 at:
Physiological tests in vitro
Adherence tests in vitrof
MST Log10 CFU/g kidney Wt change (day 0 to day 3) Clade ABC type MAT type 30°C 37°C 40°C Biofilm formation (supernatant OD600) Growth (OD600) in YCB-BSAe at 30°C Acid phosphatase sp act (nmol/15 min/OD600) Alcian blue stain (μg bound per cell OD600) Growth in 2 M NaCl BECs with Cal (%) Cal/BEC Catheter plasticg
J990102b 2 5 6 13 3 B a 0.18 0.23 0.18 0.07 0.09 388 87 34 2.3 1.2
YsU751b 6 1 7 14 1 A a 0.17 0.23 0.11 0.02 0.07 672 112 + 27 1.9 1.4
AM2002/0087b 12 2 4 18 1 A a 0.17 0.23 0.13 0.03 1.41 210 92 + 38 1.6 1.0
J981318b 3 13 3 19 1 A a 0.11 0.24 0.16 0.02 0.11 319 79 + 31 2.3 1.4
J951361b 1 20 2 23 1 A a 0.17 0.20 0.14 0.01 0.42 232 72 30 1.7 1.4
L1086b 8 3 13 24 4 B a 0.16 0.23 0.18 0.04 1.45 512 114 26 1.3 1.3
AM2003-020b 13 6 9 28 4 C a 0.16 0.29 0.14 0.03 0.16 296 108 + 27 1.6 1.7
IHEM16614b 5 15 8 28 2 A a 0.15 0.22 0.17 0.03 0.20 149 131 21 1.8 1.6
SC5314b 4 24 1 29 1 A a 0.15 0.27 0.18 0.00 0.11 530 76 + 27 2.0 1.3
AM2003/0191b 7 14 10 31 2 A a 0.16 0.21 0.16 0.05 0.61 270 122 + 35 2.5 1.1
s20152.082b 19 4 12 35 4 C a 0.17 0.23 0.18 0.05 0.12 436 123 25 2.1 1.7
IHEM16972b 9 18 16 43 2 A a 0.17 0.21 0.16 0.02 0.28 192 70 22 1.8 1.0
FJ9b 22 7 15 44 1 A a 0.17 0.16 0.12 0.03 0.36 610 72 + 35 2.1 1.1
s20152.013b 23 16 5 44 4 A a 0.16 0.27 0.16 0.02 0.12 320 84 27 2.1 1.0
73/025c 18 9 19 46 3 B a 0.17 0.19 0.13 0.05 0.07 509 78 39 2.1 1.2
AM2003-013c 14 17 17 48 1 A a 0.18 0.25 0.11 0.02 0.09 832 101 + 28 2.5 1.1
FC22c 17 8 23 48 2 A a 0.18 0.23 0.16 0.06 0.64 432 144 24 1.6 1.3
s20122.073c 10 27 11 48 4 B a 0.06 0.13 0.07 0.12 0.06 624 111 36 2.7 1.1
T101c 16 19 21 56 3 B a/a 0.11 0.15 0.10 0.02 1.37 680 82 39 2.5 1.1
s20175.016c 35 10 14 59 4 C a 0.13 0.23 0.11 0.25 0.11 957 107 16 1.8 0.8
J981315c 15 29 18 62 3 B a/α 0.18 0.28 0.15 0.05 0.10 455 88 34 2.0 1.5
IHEM16945c 20 21 24 65 2 A α/α 0.15 0.18 0.15 0.00 0.53 231 134 26 2.0 1.3
AM2003/0182c 28 12 30 70 2 A a 0.15 0.21 0.16 0.02 0.10 442 110 + 36 2.0 1.2
AM2003/0100c 25 28 22 75 2 A a 0.12 0.13 0.12 0.03 0.43 144 61 33 2.5 1.5
AM2004/0028c 24 22 29 75 2 A a 0.15 0.19 0.12 0.02 0.08 365 97 29 1.9 0.7
J981301c 37 11 28 76 1 A a 0.18 0.26 0.11 0.01 0.08 387 80 + 30 2.3 0.6
s20176.079c 26 26 27 79 4 A a 0.16 0.20 0.11 0.03 0.06 273 108 + 20 1.5 1.4
AM2003-016c 31 32 20 83 1 A a 0.16 0.25 0.11 0.01 0.09 596 78 + 30 2.3 1.5
AM2003/0089c 21 37 26 84 2 A a 0.16 0.20 0.14 0.01 0.32 124 79 + 21 1.7 1.2
b30708/5d 11 31 43 85 3 B a 0.18 0.24 0.13 0.07 0.10 539 92 34 1.5 1.5
HUN68d 30 23 34 87 4 B a 0.16 0.24 0.15 0.02 0.32 582 109 23 1.6 1.8
HUN92d 29 40 25 94 1 A a 0.12 0.30 0.07 0.06 0.07 701 112 + 21 2.1 1.4
AM2003/0165d 27 38 32 97 3 B α/α 0.12 0.13 0.16 0.00 0.11 1049 73 + 35 3.1 1.3
AM2003/0074d 38 25 35 98 3 B a 0.15 0.28 0.10 0.02 0.10 703 85 20 1.4 0.9
AM2003/0069d 32 36 33 101 2 A a 0.17 0.22 0.14 0.02 0.40 143 128 + 26 2.1 1.0
RV4688d 43 33 31 107 4 C a 0.14 0.27 0.14 0.73 0.38 1261 77 25 1.6 1.4
RIHO9d 34 34 41 109 1 A a/a 0.11 0.23 0.13 0.01 0.12 2060 86 + 33 2.0 1.0
AM2005/0377d 40 30 40 110 4 B a/a 0.13 0.13 0.05 0.00 0.85 542 27 31 2.3 1.2
81/064d 33 39 39 111 1 A α/α 0.16 0.21 0.14 0.01 0.02 388 145 + 26 1.9 1.3
FC28d 36 41 36 113 3 B α/α 0.17 0.24 0.11 0.02 0.18 504 81 42 2.0 1.2
IHEM3742d 42 35 38 115 4 C a/α 0.13 0.22 0.13 0.83 0.43 1238 74 28 1.8 0.3
HUN96d 41 42 37 120 1 A a/α 0.12 0.20 0.16 0.01 0.07 2522 95 + 24 2.1 1.2
78/028d 39 43 42 124 1 A a/α 0.13 0.20 0.09 0.00 1.32 225 111 + 20 1.5 0.9
a

Isolates are listed in decreasing order of virulence, as determined by the sum of virulence ranks (fifth column from the right).

b

Isolates ranked as highly virulent.

c

Isolates ranked as intermediate in virulence.

d

Isolates ranked as low virulence.

e

YCB-BSA, yeast carbon base with bovine serum albumin.

f

Cal, C. albicans.

g

% reduction Alamar blue per g catheter.