Fig. 1.

Identification of an Sgk1 variant. A: intron-exon organization of human Sgk1. Upstream exons 1a, 1b, and 1c splice with exon 2 to create Sgk1_v2. The predicted translation start codon is in exon 1a. B: Sgk1 protein with the variant NH₂ terminus shown as an open box (reference Sgk1) and a hatched box (Sgk1_i2) and common sequence is shown as a closed box. Known key residues and motifs are shown. Numbering of amino acids corresponds to that for Sgk1. C: comparison of the NH₂ termini of human (translation of AK055077) and mouse sgk1_i2 (AAH70401) demonstrates significant homology. Identical residues are indicated by an * and the position of individual exons is shown below. Also shown are the 25 amino acids NH₂ terminus of reference hSgk1 which differs completely from the NH₂ terminus of Sgk1_i2.