Table 2.
Up-regulated genes correlated with lymphatic metastasis
| Gene name | Symbola | Accessionb | Fold changec | pN1:pN0d |
| Cell adhesion proteins | ||||
| CD58 antigen, (lymphocyte function-assocoated antigens) | CD58 | NM_001779 | 7.75 | 2.28 |
| Integrin αM | ITGAM | NM_000632 | 5.04 | 2.06 |
| Integrin β5 | ITGB5 | NM_002213 | 3.98 | 1.87 |
| Opioid-binding protein/cell adhesion molecule-like | OPCML | NM_002545 | ||
| Cell membrane receptor | ||||
| CD86 antigen, (CD28 antigen ligand 2, B7-2 antigen) | CD86 | NM_006889 | 6.76 | 2.33 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | JUN | NM_002228 | 7.43 | 2.27 |
| Met proto-oncogene (hepatocyte growth factor receptor) | MET | NM_000245 | 10.11 | 3.46 |
| EphA2 | EPHA2 | NM_004431 | 8.26 | 2.13 |
| Epidermal growth factor receptor [avian erythroblastic leukemia viral (v-erb-b) oncogene homolog] | EGFR | NM_005228 | 8.35 | 2.62 |
| Cell death regulator | ||||
| BCL2/adenovirus E1B 19kDa interacing protein 3 | BNIP3 | NM_004052 | 3.88 | 2.29 |
| Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | SEMA4D | NM_006378 | 5.71 | 3.64 |
| Intracellular signaling | ||||
| Rho GDP dissociation inhibitor γ | ARHGDIG | NM_001175 | 5.37 | 1.97 |
| Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | RAC3 | AK054993 | 4.63 | 2.07 |
| Insulin-like growth factor binding protein 3 | IGFBP3 | M35878 | 5.39 | 2.15 |
| Coagulation factor II (thrombin) receptor | F2R | NM_001992 | 6.17 | 2.43 |
| Growth/differentiation factor | ||||
| Vascular endothelial growth factor C | VEGFC | NM_005429 | 5.68 | 2.47 |
| Cell cycle regulator | ||||
| Cyclin D1 (PRAD1: parathyroid adenomatosis 1) | CCND1 | NM_053056 | 11.56 | 4.31 |
| Cyclin-dependent kinase 4 | CDK4 | NM_000075 | 8.73 | 3.59 |
| Others | ||||
| Tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) | TIMP3 | NM_000362 | 3.95 | 1.89 |
| Ubiquitin-conjugating enzyme E2A (RAD6 homolog) | UBE2A | NM_003336 | 4.38 | 1.95 |
| v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | YES1 | NM_005433 | 5.66 | 2.37 |
| P450(cytochrome) oxidoreductase | POR | AF258341 | 4.74 | 1.99 |
| Matrix metalloproteinase 13 | MMP13 | NM_00247 | 5.67 | 2.45 |
| Matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase) | MMP2 | NM_004530 | 7.13 | 3.36 |
a
Symbol in LocusLink database;
b
GeneBank accession number;
c
Fold change, ratio of mean expression values in lymph node metastasis cases (cancer cells vs non-cancerous cells);
d
pN1:pN0, ratio of mean expression values (lymph node positive cases to lymph node negative cases).