Table 3.
Down-regulated genes correlated with lymphatic metastasis
| Gene name | Symbola | Accessionb | Fold changec | pN1:pN0d |
| Cell adhesion proteins | ||||
| Desmoplakin (DPI, DPII) | DSP | NM_004415 | -14.22 | 0.24 |
| Protocadherin gamma subfamily C, 3 | PCDHGC3 | NM_002588 | -7.88 | 0.41 |
| Integrin, beta 4 | ITGB4 | NM_000213 | -13.39 | 0.26 |
| Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | ITGA3 | NM_002204 | -6.24 | 0.38 |
| Catenin (cadherin-associated protein), alpha 1 (102kD) | CTNNA1 | NM_001903 | -8.53 | 0.37 |
| Cadherin 1, type 1, E-cadherin (epithelial) | CDH1 | NM_004360 | -15.85 | 0.25 |
| Cell cycle regulator | ||||
| Cell division cycle 25B | CDC25B | NM_021784 | -6.90 | 0.46 |
| Cyclin-dependent kinase 5 | CDK5 | NM_004935 | -5.51 | 0.48 |
| Cyclin D2 | CCND2 | NM_001759 | -6.29 | 0.43 |
| Microtubule-associated protein, RP/EB family, member 1 | MAPRE1 | NM_012325 | -13.16 | 0.29 |
| Protein phosphatase 1D | PPM1D | NM_003620 | -11.77 | 0.39 |
| Ataxia telangiectasia and Rad3 related | ATR | NM_001184 | -7.86 | 0.41 |
| Protein phosphatase 2, regulatory subunit B (B56), alpha isoform | PPP2R5A | NM_006243 | -3.89 | 0.49 |
| Intracellular signaling | ||||
| Mitogen-activated protein kinase 14 | MAPK14 | NM_001315 | -5.67 | 0.43 |
| Mitogen-activated protein kinase 7 | MAPK7 | NM_002749 | -7.15 | 0.39 |
| Mitogen-activated protein kinase 4 | MAPK4 | NM_002747 | -3.83 | 0.32 |
| Small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant) | SCYB13 | NM_006419 | -4.58 | 0.46 |
| Signal transducer and activator of transcription 5B | STAT5B | NM_012448 | -8.13 | 0.37 |
| Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 | SERPINB1 | NM_030666 | -4.47 | 0.48 |
| Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 | SERPINB2 | NM_002575 | -5.72 | 0.41 |
| SH3-domain binding protein 2 | SH3BP2 | AB000462 | -3.29 | 0.52 |
| G protein-coupled receptor kinase 6 | GPRK6 | NM_002082 | -14.12 | 0.29 |
| GTP-binding protein ragB | RAGB | NM_016656 | -6.77 | 0.46 |
| Protein tyrosine phosphatase, receptor type, F | PTPRF | NM_002840 | -7.21 | 0.34 |
| Cell membrane receptor | ||||
| EphB6 | EPHB6 | NM_004445 | -12.88 | 0.38 |
| Kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4) | KAI1 | NM_002231 | -2.24 | 0.67 |
| Small inducible cytokine subfamily A (Cys-Cys), member 25 | SCYA25 | NM_005624 | -3.76 | 0.72 |
| Monoglyceride lipase | MGLL | NM_007283 | -4.66 | 0.43 |
| Interferon (alpha, beta and omega) receptor 1 | IFNAR1 | NM_000629 | -2.39 | 0.81 |
| Insulin-like growth factor binding protein 6 | IGFBP6 | NM_002178 | -3.53 | 0.62 |
| Metabolic enzyme | ||||
| Serine protease inhibitor, Kunitz type, 2 | SPINT2 | NM_021102 | -5.44 | 0.46 |
| Protein phosphatase 2, regulatory subunit B (B56), alpha isoform | PPP2R5A | NM_006243 | -7.12 | 0.37 |
| Protein tyrosine phosphatase, non-receptor type 2 | PTPN2 | NM_002828 | -19.73 | 0.23 |
| Deoxyribonuclease I-like 3 | DNASE1L3 | NM_004944 | -8.23 | 0.29 |
| Cathepsin L | CTSL | NM_001912 | -4.39 | 0.37 |
| Cell death regulator | ||||
| Caspase 3, apoptosis-related cysteine protease | CASP3 | NM_004346 | -14.57 | 0.29 |
| Programmed cell death 10 | PDCD10 | NM_007217 | -7.19 | 0.36 |
| DNA damage response | ||||
| Ataxia telangiectasia and Rad3 related | ATR | NM_001184 | -4.78 | 0.48 |
| X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD) | XRCC5 | NM_021141 | -2.59 | 0.73 |
| Mouse double min 2 | MDM2 | NM_002392 | -6.37 | 0.51 |
| Growth/differentiation factor | ||||
| Bone morphogenetic protein 5 | BMP5 | NM_021073 | -2.78 | 0.53 |
| Keratin 4 | KRT4 | NM_002272 | -3.12 | 0.62 |
| Keratin 13 | KRT13 | NM_002274 | -4.24 | 0.48 |
| Connective tissue growth factor | CTGF | NM_001901 | -5.51 | 0.42 |
| Others | ||||
| Heat shock 70kDa protein 4 | HSPA4 | AB023420 | -3.19 | 0.56 |
| Retinoid X receptor, α | RXRA | NM_002957 | -2.89 | 0.77 |
| Ubiquitin-activating enzyme E1-like | UBE1L | NM_003335 | -2.95 | 0.53 |
| Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | SLC25A5 | NM_001152 | -6.18 | 0.46 |
a
Symbol in LocusLink database;
b
GeneBank accession number;
c
Fold change, ratio of mean expression values in lymph node metastasis cases (cancer cells vs non-cancerous cells);
d
pN1:pN0, ratio of mean expression values (lymph node positive cases to lymph node negative cases).