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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Aug 14;18(18):4982–4987. doi: 10.1016/j.bmcl.2008.08.022

Table 3.

Predicted Cell Membrane Permeability a, b

2 6c 13 17 Ranges
(nm/sec)
<25 poor,
Caco2 242 84.9 81.8 249.7 >500 great
<25 poor,
MDCK 439.3 35.1 128.8 491.9 >500 great
a

Schrodinger’s Qikprop employed for these calculations

b

Highlighted numbers in red denote compound’s property value borders range value of 95% of known drugs.