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Role of proteasome inhibition in histone acetylation. A: Proteasome inhibition caused a significant increase in histone acetylation as shown in the liver nuclear extracts of rats fed ethanol and in the liver nuclear extracts of rats given PS-341(B). C: p300 protein level was increased in the nuclear extract from the livers of rats fed ethanol chronically, and in the liver nuclear extracts of rats given PS-341, as shown by real time PCR (D), P = 0.003. (mean ± SE, n = 3).
