Table 3.
Elements, processes, and their parameters incorporated into the OT simulation model
| Elements/processes | Element abbreviation/process # | Type | Parameter |
| Odorant | -- | Element | Initial value = 10a |
| Olfactory receptor | OR | Element | Initial value = 0 (default) |
| OR-odorant complex | OR-odorant | Element | Initial value = 0 (default) |
| G protein olfactory type | G(olf) | Element | Initial value = 0 (default) |
| Adenylate cyclase | AC | Element | Initial value = 0 (default) |
| Cyclic adenylic acid | cAMP | Element | Initial value = 0 (default) |
| Cyclic nucleotide gated channel | CNG | Element | Initial value = 0 (default) |
| Calcium ion | Ca2+ | Element | Initial value = 0 (default) |
| Chloride channel regulator | CLCA | Element | Initial value = 0 (default) |
| Chloride ion | Cl- | Element | Initial value = 0 (default) |
| Calmodulin | CaM | Element | Initial value = 0 (default) |
| Phosphodiesterase 1C | PDE1C | Element | Initial value = 0 (default) |
| Guanylate cyclase activator | GCAP | Element | Initial value = 0 (default) |
| Guanylate cyclase | pGC | Element | Initial value = 0 (default) |
| Guanosine 3',5'-cyclic phosphate | cGMP | Element | Initial value = 0 (default) |
| Protein kinase, cGMP-dependent | PKG | Element | Initial value = 0 (default) |
| Ca2+/CaM-dependent protein kinase | CaMK2 | Element | Initial value = 0 (default) |
| cAMP-dependent protein kinase α | PKA | Element | Initial value = 0 (default) |
| Phosducin | Phd | Element | Initial value = 0 (default) |
| Translation | 1 | Process | Rate = OR*0.05b |
| Degradation | 2 | Process | Rate = OR*0.05b |
| Binding | 3 | Process | Rate = Odorant*OR*0.7c |
| Dissociation | 4 | Process | Rate = Odorant-OR*0.5c |
| Activation | 5 | Process | Threshold = 2d |
| Activation | 6, 8, 10, 14, 15 21, 22, 24, 25, 26 |
Process | Threshold = 0 (default) |
| cAMP increase | 7 | Process | Threshold = 0 (default) |
| Ion transport | 9 | Process | Threshold = 0 (default) |
| Ion transport (depolarization) | 11 | Process | Threshold = 0 (default) |
| Degradation | 12 | Process | Rate = Cl- *0.8e |
| Degradation | 13 | Process | Rate = 1.0 (default)f |
| Suppression | 16, 27, 28 | Process | Threshold = 0 (default) |
| Activation | 17 | Process | Threshold = 0 (default)g |
| cAMP decomposition | 18 | Process | Threshold = 0g or 1g |
| Activation | 19 | Process | Threshold = 0 (default)h |
| cAMP decomposition | 20 | Process | Threshold = 0h or 1h |
| cGMP increase | 23 | Process | Threshold = 0 (default) |
a Changing this value (5–20) did not affect the results of the simulation.
b Processes 1 and 2 kept the OR at a constant concentration.
c Processes 3 and 4 recovered the OR to its initial concentration after consumption of the odorants.
d Determined a priori by test runs. If the threshold was 0, the simulation model did not work and resulted in computation error.
e Process 12 recovered the polarization state of the olfactory receptor neutron model.
f Process 13 was applied in the Ca2+-limited model.
g Processes 17 and 18 were applied in the single PDE1C model.
h Processes 19 and 20 were applied in the multiple PDE1C model.