Table 1.

Model parameters and estimations

parameter	description	baseline value	references
1/μA	mean infectious period of asymptomatic infection	4.1 days	[3,6,7]
1/μU	mean infectious period of untreated symptomatic infection	4.1 days	[3,6,7]
1/μT	mean infectious period of treated symptomatic infection	4.1 days	[3,6,7]
dU	death rate of untreated symptomatic infection	0.002 day-1	[12,19]
dT	death rate of treated symptomatic infection	0.001 day-1	[12,19]
dU,r	death rate of resistant infection (low fitness)	0.0002 day-1	[12,19]
dr,U	death rate of resistant infection (high fitness)	0.0008 day-1	[12,19]
δ A	relative transmissibility of asymptomatic infection	0.142	[6,7,19]
δ T	relative transmissibility of treated symptomatic infection	0.4	[3,12,19]
δ r	relative transmissibility of resistant strain (high fitness)	0.9	[19,27]
p	probability of developing clinical symptoms	0.67	[6,7]
α	rate of emergence of de novo resistance	0.018 day-1	[19,25]
γ	rate of conversion between resistant mutants	0.0036 day-1	[19,25]
q	treatment level	variable

Description of the model parameters with their values obtained from the published literature.