Figure 3.

Kinetics of sodium channel activation and inactivation. (A) Voltage dependant steady state activation (n = 10,11, and 8 for WT, p.R965C, and p.1876insM respectively) and steady state inactivation (n = 10,11, and 8 for WT, p.R965C, and p.1876insM respectively). *, p < 0.05; **, p < 0.01 when compared to WT using one way ANOVA followed by Tukey test (B) Time constant of inactivation. This was accessed by fitting the decaying phase of current trace obtained as in Figure 2A with one exponential equation: Y = Aexp(-t/τ) + C. *, p < 0.05 when compared to WT