Table 1.
Effects of genistein, EGF, 17β-estradiol and combinations of genistein with EGF or 17β-estradiol on accumulation of lysosomes containing complex storage structures in MPS IIIA fibroblasts
| Cells | Added agents | a Average number of complex storage structures per 100 μm2 | ||
| Genistein (μM) | EGF (ng/ml) | 17β-estradiol (nM) | ||
| Control | 0 | 0 | 0 | 2 |
| MPS IIIA | 0 | 0 | 0 | 38 |
| MPS IIIA | 10 | 0 | 0 | 7 |
| MPS IIIA | 30 | 0 | 0 | 5 |
| MPS IIIA | 0 | 100 | 0 | 67 |
| MPS IIIA | 10 | 100 | 0 | 26 |
| MPS IIIA | 30 | 100 | 0 | 11 |
| MPS IIIA | 0 | 0 | 1 | 21 |
| MPS IIIA | 10 | 0 | 1 | 13 |
| MPS IIIA | 30 | 0 | 1 | 8 |
a Electron micrographs obtained as shown in Fig. 2 were analyzed by counting complex storage structures per 100 μm2.