Table 3.
Improvement in secondary outcomes over time (from baseline to 16, 26, and 52 weeks)
| Secondary outcome variable | Baseline Adj. mean (SE) | Week 16 Adj. mean (SE) | Week 26 Adj. mean (SE) | Week 52 Adj. mean (SE) |
| Brief Symptom Inventory, global severity | 60.34 (0.30) | 52.41a (0.37) | 52.19a (0.40) | 51.89a (0.41) |
| Perceived Stress Scale, total | 5.79 (0.08) | 4.16a (0.10) | – | 4.32a (0.10) |
| Percentage days paid for work | 87.65 (0.75) | 91.93a (0.61) | 89.57a,b (0.71) | 87.55b,c (0.79) |
| SF-12 physical health score | 52.65 (0.24) | 53.61a (0.21) | – | 51.88a,b (0.27) |
| SF-12 mental health score | 41.45 (0.32) | 49.44a (0.30) | – | 48.01a,b (0.34) |
| WHOQOL Physical Health domain | 69.99 (0.47) | – | 73.29a (0.61) | 76.85a,c (0.54) |
| WHOQOL Psychological domain | 59.38 (0.52) | – | 64.44a (0.65) | 66.08a,c (0.61) |
| WHOQOL Social Relationships domain | 56.88 (0.63) | – | 65.53a (0.68) | 65.63a (0.68) |
| WHOQOL Environment domain | 63.40 (0.55) | – | 69.88a (0.58) | 69.91a (0.58) |
| Craving, obsessive-compulsive total | 25.35 (0.22) | 10.10a (0.27) | 11.91a,b (0.31) | – |
| Percentage days of mutual help meetings | 13.37 (1.14) | 22.01a (1.14) | 21.66a (1.35) | 21.97a (1.44) |
Notes: Mixed-model estimates (lsmeans) are based on a full model that adjusts for clinical center, each treatment effect, all two-and three-way interaction terms, and time period. SF-12 = Short Form-12; WHOQOL = World Health Organization Quality of Life.
a
Different from baseline mean
b
different from Week 16 mean
c
different from Week 26 mean. All significant differences are at p < .05.