Table 1. Top SNPs selected by Evaporative Cooling (EC) as most relevant to smallpox vaccine-associated adverse events.
| SNP ID | dbSNP ids | Gene Name | EC Score |
| ESR1-13 | 56525559 | estrogen receptor 1 | −1.551 |
| HSD17B4-19 | 21184487 | hydroxysteroid (17-beta) dehydrogenase 4 | −1.422 |
| GSK3B-01 | 26231979 | glycogen synthase kinase 3 beta | −1.174 |
| GSK3B-27 | 26255314 | glycogen synthase kinase 3 beta | −1.167 |
| CASR-06 | 28496245 | calcium-sensing receptor | −0.727 |
| ALOX5-15 | 3320405 | arachidonate 5-lipoxygenase | −0.701 |
| RXRA-03 | 208756 | retinoid X receptor, alpha | −0.633 |
| AHR-17 | 16862729 | aryl hydrocarbon receptor | −0.627 |
| CD4-03 | 6783008 | CD4 molecule | −0.605 |
| SCUBE2-02 | 7859381 | signal peptide, CUB domain, EGF-like 2 | −0.597 |
| ARNT-23 | 1340390 | aryl hydrocarbon receptor nuclear translocator | −0.562 |
| LIPC-08 | 29629829 | lipase, hepatic | −0.561 |
| OPRD1-03 | 11986807 | opioid receptor, delta 1 | −0.538 |
| GSK3B-04 | 26074026 | glycogen synthase kinase 3 beta | −0.493 |
| MTHFR-02 | 1801133 | 5,10-methylenetetrahydrofolate reductase (NADPH) | −0.487 |
| GSK3B-07 | 26090649 | glycogen synthase kinase 3 beta | −0.483 |
| EXO1-02 | 6787940 | exonuclease 1 | −0.480 |
| MTHFR-02-2 | 6393745 | 5,10-methylenetetrahydrofolate reductase (NADPH) | −0.478 |
| SLC6A3-14 | 1419969 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | −0.476 |
| CYBB-12 | 488277 | cytochrome b-245, beta polypeptide | −0.390 |
| IL4-01 | 34424167 | interleukin 4 | −0.366 |
| NFKB1-14 | 28084004 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | −0.321 |
| IL4-03 | 34424723 | interleukin 4 | −0.312 |
| CBR3-01 | 23169639 | carbonyl reductase 3 | −0.302 |
| IL2-03 | 47925629 | interleukin 2 | −0.288 |
| IL4-10 | 34433182 | interleukin 4 | −0.238 |
The EC score cutoff was selected by random permutation analysis, yielding a .05 risk that a SNP declared relevant on this list is actually irrelevant to the phenotype. SNPs sorted from best to worst EC score; a lower score means more relevance to the phenotype. SNPs are named according to their SNP500Cancer id (http://snp500cancer.nci.nih.gov/) in the first column and by dbSNP number (build 129) in the second column.