Table 4.
Factors associated with B cell depletion 1 mo after rituximab initiation
| Factor | B cell depletion at M1
|
P | |
|---|---|---|---|
| +
|
-
|
||
| (n = 12) | (n = 5) | ||
| Median age, years (range) | 23 (18 to 35) | 24 (17 to 37) | NS |
| Black ethnicity, n (%) | 2 (17%) | 4 (80%) | 0.027 |
| Median Pu, g/j (range) | 5.7 (0.2 to 25) | 8 (2.7 to 9.5) | NS |
| Median serum Alb, g/L (range) | 24.5 (20 to 40) | 18 (11 to 27) | 0.03 |
| Median eGFR, ml/min/1.73 m2 (range) | 70 (9 to 150) | 102 (16 to 133) | NS |
| Median C3, % normal (range) | 44 (15 to 96) | 39 (30 to 130) | NS |
| Median C4, % normal (range) | 34 (17 to 78) | 26 (21 to 101) | NS |
B cell depletion is defined as CD19 + cells ≤5/mm3 and ≤1%. P values are by Fisher's exact test for categorical data and by Wilcoxon rank sum test with continuity correction for continuous data. NS, not significant; Pu, baseline proteinuria; Serum Alb, baseline albuminemia; eGFR, baseline estimated glomerular filtration rate; C3: baseline C3 complement; C4: baseline C4 complement.