Figure 4.

IL-6 KO prevents the reduction in IRS-1 and Akt phosphorylation which is induced by AngII infusion. (A) The levels of IRS-1 and p-Akt in gastrocnemius muscles of WT and IL-6 KO mice after 7 d of PBS or AngII infusion were detected by Western blot. (B) Differences in the densities of IRS-1 (corrected for β-actin; left), p-Akt (corrected for total Akt; right) from A are shown. Values from mice infused with AngII minus value in PBS-infused mice were calculated from five mice in each group.