Figure 4.

Total urinary protein excretion. (A) Total protein excretion in 12-wk diabetic and age-matched control rats demonstrated significantly increased total urinary protein excretion in the diabetic versus control groups (P < 0.01 control versus diabetic; control n = 4, diabetic n = 4). (B) Fractional clearance of [¹⁴C]albumin in 12-wk diabetic rats demonstrates an approximately 2.2-fold increase in total albumin excretion (P < 0.001 control versus diabetic; control n = 7, diabetic n = 9). (C) Total protein excretion (▪) at 4 d after STZ-induced diabetes induction resulted in significantly increased total protein excretion that could be prevented through strict glycemic control (P < 0.05 control versus diabetic; P < 0.05 diabetic versus diabetic + insulin). Analysis of intact albumin excretion by ELISA (□) reveals no significant increase in intact albumin excretion 4 d after STZ-induced diabetes induction despite significant and relatively considerable increases in total protein excretion (control n = 3, diabetic n = 3, diabetic + insulin n = 3). NS, not significant.