Figure 8.
(A) Effect of tubular fluid–flow rate on JNa and JK in the presence or absence of 10 μM MS-PPOH. The rabbit CCD was treated with MS-PPOH (n = 3) or vehicle (n = 3) for 10 min before experiments, and 10 μM MS-PPOH was present throughout the entire experiments. (B) Effect of MS-PPOH (10 μM) and luminal IBX (50 nM) + MS-PPOH on JNa (left) and JK (right) in CCDs perfused at 5 nl/mm per min. Control measurements were determined in the absence of the inhibitors. *Significant difference (P < 0.05).