Figure 14.

Effect of BMP-7 on thickness of peritoneal membrane. (A) Trichrome-stained parietal peritoneum of abdominal wall shows a marked increase in submesothelial matrix in group D (dialysis), which is ameliorated by peritoneal rest (group R). Adv-BMP-7 transfection (group B) further decreases peritoneal thickening compared with groups R and L (Adv-LacZ transfection). (B) The peritoneal thickness/body weight (μm/g) assessed by morphometric analysis is increased in group D compared with group C (control) and group R, which is further decreased in group B. *P < 0.05 versus other groups; †P < 0.05 versus groups D, R, and L. Horizontal lines at the top, middle, and bottom of the boxes show the 75th, 50th, and 25th percentiles, respectively, and vertical lines above and below the boxes show the 90th and 10th percentiles, respectively. Magnification, ×400.