. Author manuscript; available in PMC: 2010 Feb 1.

Published in final edited form as: DNA Repair (Amst). 2008 Dec 5;8(2):182–189. doi: 10.1016/j.dnarep.2008.10.006

Table 1. Mutation frequencies categorized by mutation types.

	HSV-tk frequency × 10^-4
Mutation type	ENEYP	WT	Fold increase over wild type
Mutation frequency	267±39^c	42±7.8	6.7
Base substitutions (independent)^a	59(19)^b	10 (26)	5.9
Frame shifts (independent)	168 (54)	25 (64)	6.7
Large deletions (independent)	15 (5)	3.6(9)	4.3
Tandem and complex tandem errors (independent)	3.5 (8)	1.2 (3)	2.1
No. of independent mutations	86	102

Independent mutations are present as single mutations in a clone or as mutations that are greater than 15 bases apart in a single clone.

The numbers in parentheses are the number of events observed.

This represents the standard deviation. WT values are from Eckert et al. (2002) and K.E. unpublished data.