Table.
Kv and Kir Currents in Sham and TAC LV, RV, EPI, and ENDO Myocytes
| Cells | Cm | Ipeak | Ito,f | IK,slow | Iss | IK1 |
|---|---|---|---|---|---|---|
| Sham | ||||||
| LV | 132±3 | |||||
| τd | 84±3 | 1281±23 | ||||
| pA | 6849±306 | 3533±219 | 2408±96 | 714±20 | −1474±48 | |
| pA/pF | 52.5±2.2 | 27.1±1.6 | 18.4±0.7 | 5.5±0.1 | −11.2±0.2 | |
| n | 73 | 60 | ||||
| RV | 130±5 | |||||
| τd | 74±3 | 1155±28 | ||||
| pA | 8909±607 | 5087±417 | 2702±157 | 690±33 | −1618±75 | |
| pA/pF | 68.3±3.8 | 38.9±2.8 | 20.7±0.9 | 5.3±0.1 | −12.6±0.5 | |
| n | 35 | 26 | ||||
| EPI | 138±7 | |||||
| τd | 87±5 | 1191±40 | ||||
| pA | 8393±519 | 4105±308 | 3031±193 | 787±49 | −1427±105 | |
| pA/pF | 61.6±3.2 | 30.2±2.2 | 22.3±1.3 | 5.7±0.2 | −10.4±0.5 | |
| n | 13 | 13 | ||||
| ENDO | 131±10 | |||||
| τd | 89±13 | 1434±51 | ||||
| pA | 5131±469 | 2335±203 | 2010±214 | 686±62 | −1579±110 | |
| pA/pF | 39.8±2.3 | 18.3±1.3 | 15.3±0.9 | 5.3±0.3 | −12.4±0.6 | |
| n | 16 | 16 | ||||
| TAC | ||||||
| LV | 172±5* | |||||
| τd | 82±2 | 1553±39 | ||||
| pA | 5744±314§ | 3149±235 | 1747±83* | 807±26# | −1459±50 | |
| pA/pF | 34.1±1.8* | 18.8±1.4* | 10.4±0.4* | 4.7±0.1* | −8.6±0.3* | |
| n | 70 | 57 | ||||
| RV | 122±5 | |||||
| τd | 66.4±2 | 1286±39 | ||||
| pA | 7123±570 | 4406±386 | 1858±150 | 662±38 | −1398±155 | |
| pA/pF | 58.4±4.1 | 36.1±2.7 | 15.2±1.1 | 5.4±0.2 | −11.4±1 | |
| n | 21 | 12 | ||||
| EPI | 177±9# | |||||
| τd | 56±2 | 1596±53 | ||||
| pA | 5754±471*b | 3684±354 | 1167±107*a | 802±57 | −1310±88 | |
| pA/pF | 32.9±2.4*b | 21.1±1.9# | 6.7±0.6*a | 4.6±0.3# | −7.1±0.4* | |
| n | 23 | 21 | ||||
| ENDO | 215±11*a | |||||
| τd | 70±3 | 1626±74 | ||||
| pA | 5642±584 | 2719±369 | 1856±182 | 1039±73*a | −1720±99 | |
| pA/pF | 26.8±2.5* | 13.2±1.7§ | 8.7±0.8* | 4.8±0.2 | −7.9±0.4* | |
| n | 18 | 19 |
All values are means±SEM. Cm, τ decay (τd), amplitude, and density values are expressed in pF, ms, pA, and pA/pF, respectively. Kv and Kir densities were determined at +40 and −120 mV (HP=−70 mV), respectively.
Values were compared in TAC and sham LV myocytes, in TAC and sham EPI myocytes, or in TAC and sham ENDO myocytes, and *P<0.001 #P<0.01, §P<0.05 values are indicated.
Impact of LVH is significantly (aP<0.05, bP<0.01) different in EPI and ENDO myocytes.