Table 2.
The five MUTYH variants and their association with endometrial cancer risk
| Polymorphisms | Genotype | Cases n (%) | Controls n (%) | X2 | OR (95% CI) and p value |
| MUTYH Y165C (A>G) | AA | 190 (99.5) | 120 (100) | 1.00 (reference) | |
| AG | 1 90.5) | 0 (0.0) | P = 0.43 | 0.53 (0.02–13.1) p = 0.43 | |
| GG | 0 (0.0) | 9 (0.0) | |||
| MUTYH G382D (G>A) | GG | 189 (99.0) | 118 (98.3) | 1.00 (reference) | |
| GA | 2 (1.0) | 2 (1.7) | p = 0.6 | 41.6 (0.22–11.5) p = 0.63 | |
| AA | 0 (0.0) | 0 (0.0) | |||
| MUTYH V22M (G>A) | GG | 172 (90.1) | 194 (85.8) | 1.00 (reference) | |
| GA | 17 (8.9) | 31 (13.7) | 1.62 (0.86–3.02) p = 0.17 | ||
| AA | 2 (1.0) | 1 (0.4) | 0.44 (0.04–4.94) p = 0.92 | ||
| MUTYH Q324H (G>C) | GG | 109 (57.1) | 129 (59.2) | 1.00 (reference) | |
| GC | 71 (37.2) | 75 (34.4) | p = 0.83 | 0.89 (0.59–1.35) p = 0.66 | |
| CC | 11 (5.8) | 14 (6.4) | 1.08 (0.4&-2.47) p = 0.86 | ||
| MUTYH S501F (C>T) | CC | 187 (97.9) | 210 (96.8) | 1.00 (reference) | |
| CT | 4 (2.1) | 7 (3.2) | p = 0.48 | 1.56 (0.45–5.41) p = 0.69 | |
| TT | 0 (0.0) | 0 (0.0) |