Table 2. Breast cancer risk associated with plasma leptin concentrations.
| Leptin level (ng ml−1) | No. of cases (%) | No. of controls (%) | Matched ORa (95% CI) | Adjusted ORb (95% CI) |
|---|---|---|---|---|
| All women | ||||
| <5.06 | 68 (22.9) | 147 (24.9) | 1.00 (reference) | 1.00 (reference) |
| 5.06–10.90 | 124 (41.8) | 299 (50.8) | 0.93 (0.63–1.38) | 0.87 (0.60–1.26) |
| >10.90 | 105 (35.3) | 143 (24.3) | 1.63 (1.07–2.49) | 1.58 (1.02–2.43) |
| Ptrend | 0.009 | 0.039 | ||
| Premenopausal | ||||
| <4.82 | 37 (21.5) | 83 (25.0) | 1.00 (reference) | 1.00 (reference) |
| 4.82–10.60 | 83 (48.3) | 168 (50.6) | 1.11 (0.68–1.75) | 0.99 (0.61–1.61) |
| >10.60 | 52 (30.2) | 81 (24.4) | 1.40 (0.83–2.38) | 1.63 (0.91–2.89) |
| Ptrend | 0.200 | 0.103 | ||
| Postmenopausal | ||||
| <5.20 | 28 (22.4) | 34 (24.9) | 1.00 (reference) | 1.00 (reference) |
| 5.20–11.50 | 47 (37.6) | 131 (50.9) | 0.78 (0.44–1.37) | 0.71 (0.40–1.26) |
| >11.50 | 50 (40.0) | 62 (24.2) | 1.69 (0.95–3.06) | 1.35 (0.70–2.60) |
| Ptrend | 0.050 | 0.324 | ||
CI=confidence interval; OR=odds ratio.
a
Odds ratios were matched on the date of enrolment and fasting status.
b
In addition to matched variables, odds ratios were also adjusted for body mass index and waist circumference.