Table 2. Distributions of clinical attributes and adjuvant therapies used in unilateral and bilateral breast cancer cases, at the time of first diagnosis.
|
Bilateral
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
Unilateral (N=1863)
|
Synchronous (N=17)
|
Metachronous (N=26)
|
Overall (N=43)
|
|||||||
| Variable | No. | % | No. | % | No. | % | No. | % | P-valuea | P-valueb |
| Tumour size (cm) | 3.3±3.7 | 4.0±2.8 | 3.5±2.0 | 3.7±2.3 | 0.33 | 0.48 | ||||
| T1 (⩽2) | 0.48 | 0.67 | ||||||||
| T1a (⩽0.5) | 16 | 0.9 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | ||
| T1b (0.5−1.0) | 100 | 5.9 | 2 | 13.3 | 1 | 5.0 | 3 | 8.6 | ||
| T1c (1.0−2.0) | 464 | 27.2 | 3 | 20.0 | 6 | 30.0 | 9 | 25.7 | ||
| T2 (2.0−5.0) | 922 | 54.1 | 6 | 40.0 | 10 | 50.0 | 16 | 45.7 | ||
| T3, T4 (>5) | 201 | 11.8 | 4 | 26.7 | 3 | 15.0 | 7 | 20.0 | ||
| Histology type | 0.18 | 0.13 | ||||||||
| IDC | 1558 | 85.4 | 12 | 80.0 | 25 | 96.2 | 37 | 90.2 | ||
| DCIS | 106 | 5.8 | 2 | 13.3 | 1 | 3.8 | 3 | 7.3 | ||
| ILC | 30 | 1.6 | 1 | 6.7 | 0 | 0.0 | 1 | 2.4 | ||
| Others | 130 | 7.1 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | ||
| Grade | 0.72 | 0.68 | ||||||||
| 1 | 126 | 29.7 | 2 | 66.7 | 1 | 20.0 | 3 | 37.5 | ||
| 2 | 206 | 48.6 | 1 | 33.3 | 2 | 40.0 | 3 | 37.5 | ||
| 3 | 92 | 21.7 | 0 | 0.0 | 2 | 40.0 | 2 | 25.0 | ||
| Oestrogen receptor | 0.04 | 0.03 | ||||||||
| Positive | 871 | 64.2 | 4 | 26.7 | 12 | 63.2 | 16 | 47.1 | ||
| Negative | 485 | 35.8 | 11 | 73.3 | 7 | 36.8 | 18 | 52.9 | ||
| Progesterone receptor | 0.23 | 0.08 | ||||||||
| Positive | 788 | 60.2 | 5 | 33.3 | 12 | 63.2 | 17 | 50.0 | ||
| Negative | 521 | 39.8 | 10 | 66.7 | 7 | 36.8 | 17 | 50.0 | ||
| Chemotherapy | 0.13 | 0.74 | ||||||||
| Yes | 1080 | 59.8 | 12 | 75.0 | 18 | 69.2 | 30 | 71.4 | ||
| No | 725 | 40.2 | 4 | 25.0 | 8 | 30.8 | 12 | 28.6 | ||
| Radiotherapy | 0.12 | 1.00 | ||||||||
| Yes | 164 | 10.0 | 3 | 18.8 | 4 | 16.7 | 7 | 17.5 | ||
| No | 1480 | 90.0 | 13 | 81.2 | 20 | 83.3 | 33 | 82.5 | ||
| Tamoxifen | 0.31 | 0.71 | ||||||||
| Yes | 1444 | 81.4 | 12 | 80.0 | 18 | 72.0 | 30 | 75.0 | ||
| No | 331 | 18.6 | 3 | 20.0 | 7 | 28.0 | 10 | 25.0 | ||
| Axillary lymph node metastasis | 0.49 | 0.02 | ||||||||
| Yes | 599 | 44.3 | 4 | 26.7 | 15 | 65.2 | 19 | 50.0 | ||
| No | 753 | 55.7 | 11 | 73.3 | 8 | 34.8 | 19 | 50.0 | ||
| Local recurrence | 0.02 | 0.03 | ||||||||
| Yes | 203 | 11.2 | 1 | 5.9 | 9 | 36.0 | 10 | 23.8 | ||
| No | 1607 | 88.8 | 16 | 94.1 | 16 | 64.0 | 32 | 76.2 | ||
| Distant metastasis | 1.00 | 0.01 | ||||||||
| Yes | 371 | 20.5 | 0 | 0 | 8 | 32.0 | 8 | 19.0 | ||
| No | 1439 | 79.5 | 17 | 100 | 17 | 68.0 | 34 | 81.0 | ||
| Metastatic sites | ||||||||||
| Bone | 187 | 11.2 | 0 | 0.0 | 3 | 13.6 | 3 | 7.7 | 0.80 | 0.24 |
| Lung | 181 | 10.9 | 0 | 0.0 | 4 | 17.4 | 4 | 10.0 | 1.00 | 0.12 |
| Liver | 169 | 10.2 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0.045 | — |
| Brain | 64 | 4.1 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0.50 | — |
| Neck LN | 63 | 4.0 | 0 | 0.0 | 4 | 17.4 | 4 | 10.0 | 0.08 | 0.12 |
DCIS=ductal carcinoma in situ; IDC=infiltrating ductal carcinoma; ILC=infiltrating lobular carcinoma.
a
Unilateral vs Bilateral.
b
Synchronous vs Metachronous.