Table 1 Candidate genes investigated in restless legs syndrome and linkage analysis identified so far.
Candidate gene | Linkage |
---|---|
1. DA receptor genes | |
D1–D5 receptors | Nil |
DAT | Nil |
TH | Nil |
Dopamine β hydroxylase | Nil |
2. GTP cyclohydrolase | Nil |
3. GABA A receptor subunits (α1–6, β1–3, χ1–3, p1–2) | Nil |
4. α‐1 subunit of the glycine receptor (chromosome 5q31) | Nil |
5. MAO‐A | Nil |
6. MAO | Nil |
7. Neurotensin | Nil |
DA, dopamine; DAT, dopamine transporter; GABA, γ‐amonibutyric acid; GTP, guanosine triphosphate; MAO, monoamine oxidase; TH, tryosine hydroxylase.