TABLE 2.

DSS-Induced mRNA Cytokine Expression in the Colon

Mice	IFN-γ	IL-6	IL-10	TNF-α	CXCL2
WT	46.9 ± 35.2	288.9 ± 5.1	1.2 ± 0.9	2.5 ± 0.1	16.3 ± 5.8
s/s	0.2 ± 0.08a	255.0 ± 3.7b	0.9 ± 0.3	2.1 ± 0.1c	6.9 ± 3.8
db/db	1.0 ± 0.56a	0.0 ± 0.0b,d	0.1 ± 0.1	1.5 ± 0.0b,e	3.9 ± 1.9

Mice received DSS as detailed in Materials and Methods. mRNA was extracted from a snap-frozen colon taken at Day 10 and analyzed for the expression of IFN-γ, IL-6, IL-10, TNF-α, and CXCL2. Data are expressed as fold induction compared with control WT mice that did not receive DSS. 

^aP < 0.01; 

^bP < 0.001; 

^cP < 0.05 versus WT DSS; 

^dP < 0.001, 

^eP < 0.01 versus s/s DSS.