Table 5. CMS-induced changes in the expression of cytoskeleton-related genes.
| Cytoskeleton genes upregulated or downregulated in HTM after CMS | |||
|---|---|---|---|
|
Gene |
Fold |
p value |
GenBank accession number |
| Ectodermal-neural cortex (with BTB-like domain) |
4.998 |
0.0015 |
NM_003633 |
| Tubulin, beta, 4 |
4.489 |
0.00178 |
NM_006086 |
| Myosin IXB |
3.572 |
0.000919 |
NM_004145 |
| Actin related protein 2/3 complex, subunit 5-like |
3.519 |
4.30E-05 |
NM_030978 |
| Leucine rich repeat (in FLII) interacting protein 1 |
3.016 |
0.00186 |
NM_004735 |
| Syndecan 1 |
2.802 |
0.00156 |
NM_002997 |
| Chromosome 14 open reading frame 31 |
2.672 |
0.00977 |
NM_152330 |
| Kinesin family member 21A |
2.588 |
0.000145 |
AK000059 |
| Tubulin, beta polypeptide |
2.388 |
0.00293 |
NM_001069 |
| Leucine rich repeat (in FLII) interacting protein 1 |
2.212 |
0.00923 |
NM_004735 |
| Filamin C, gamma (actin binding protein 280) |
2.205 |
0.00172 |
NM_001458 |
| Paxillin |
2.168 |
0.00754 |
NM_002859 |
| Molecule interacting with Rab13 |
2.153 |
0.00962 |
AB051455 |
| Tropomyosin 3 |
2.126 |
0.0175 |
AK092712 |
| Tubulin beta MGC4083 |
2.119 |
0.00802 |
NM_032525 |
| Tubulin alpha 6 |
2.073 |
0.000692 |
NM_032704 |
| Arg/Abl-interacting protein ArgBP2 |
-4.37 |
0.000424 |
NM_021069 |
| Ankyrin repeat, family A (RFXANK-like), 2 |
-3.24 |
0.0035 |
NM_023039 |
| Protein kinase C and casein kinase substrate in neurons 3 |
-2.913 |
0.00147 |
NM_016223 |
| A kinase (PRKA) anchor protein (yotiao) 9 |
-2.604 |
0.00434 |
NM_147185 |
| Syntrophin, beta 2 |
-2.415 |
0.00777 |
NM_006750 |
| Profilin 2 |
-2.058 |
0.00371 |
NM_002628 |
| Downregulated in ovarian cancer 1 | -2.036 | 0.0402 | NM_014890 |
Cytoskeleton related genes that were significantly up- or down-regulated more than two fold after CMS in TM cells. Columns show the gene name, the fold expression change determined by microarray analysis, the calculated p value, where p<0.05 was considered to be statistically significant, and the GeneBank accession number.