Table 6. CMS-induced changes in cell adhesion genes.
| Cell adhesion genes upregulated and downregulated in HTM after CMS | |||
|---|---|---|---|
|
Gene |
Fold |
p value |
GenBank accession number |
| Integrin, beta 6 |
59.16 |
0.000405 |
NM_000888 |
| Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
5.06 |
0.0112 |
NM_002203 |
| Chondroitin sulfate proteoglycan 4 (melanoma-associated) |
4.376 |
0.000852 |
NM_001897 |
| Tumor necrosis factor, alpha-induced protein 6 |
4.082 |
0.00033 |
NM_007115 |
| Leupaxin |
3.449 |
0.000212 |
NM_004811 |
| Bystin-like |
2.625 |
0.000981 |
NM_004053 |
| Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
2.554 |
0.00151 |
NM_002205 |
| Protein tyrosine phosphatase, non-receptor type substrate 1 |
2.38 |
0.00252 |
NM_080792 |
| Integrin-linked kinase-associated serine/threonine phosphatase 2C |
2.107 |
0.00141 |
NM_030768 |
| A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 1 |
2.081 |
0.0285 |
NM_006988 |
| Chemokine (C-X3-C motif) ligand 1 |
-3.068 |
0.000683 |
NM_002996 |
| Thrombospondin 1 |
-2.883 |
0.0163 |
NM_003246 |
| Hyaluronan synthase 1 |
-2.654 |
0.00277 |
NM_001523 |
| Collagen, type VIII, alpha 1 |
-2.594 |
0.0103 |
NM_001850 |
| Plakophilin 4 |
-2.443 |
0.0446 |
NM_003628 |
| Laminin, beta 1 |
-2.443 |
0.0023 |
NM_002291 |
| Discoidin domain receptor family, member 2 |
-2.306 |
0.00879 |
NM_006182 |
| Integrin, beta-like 1 (with EGF-like repeat domains) |
-2.137 |
0.012 |
AB008375 |
| Cadherin 11, type 2, OB-cadherin (osteoblast) | -2.04 | 0.00555 | NM_033664 |
Genes involved in cell adhesion that were significantly up- or down-regulated more than two fold after CMS in TM cells. Columns show the gene name, the fold expression change determined by microarray analysis, the calculated p value, where p<0.05 was considered to be statistically significant, and the GeneBank accession number.