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. 2009 Mar;133(3):295–305. doi: 10.1085/jgp.200810125

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© 2009 Cheng et al.

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Figure 2. — KirBac1.1 currents are inhibited by PIP₂. (A) Continuous recording of potassium-selective and barium-sensitive KirBac1.1 current alternating between +100 and −100 mV clamp. The patch was moved into a 5-µM PIP₂ buffer where indicated. The gain on the amplifier was increased by 100× where indicated. (B) Continuous recording of KirBac1.1 current held at −100 mV. 50 µM diC8-PIP₂ was applied where indicated. (C) Data from recordings for PIP₂ (n = 5) and diC8-PIP₂ (n = 3) inhibition. Currents in PIP₂, diC8-PIP₂, and after 2 min of washout (post-ctrl) are normalized to the initial current (prectrl).