Table 1. Peak plasma and brain levels and 0-6-hr plasma and brain AUC of MC4-R antagonists SNT207707 and SNT207858 in CD-1 mice after oral application (n = 3 per group).

Compound	SNT207707	SNT207858
Dose [mg/kg]	60	60
Plasma peak [nM]	1960	1520
Plasma AUC [nM·h]	6373	4405
Brain peak [nM]	580	110
Brain AUC [nM·h]	2307	437
Brain/plasma ratio	0.36	0.10

Note: Brain/plasma ratio is calculated from area under the curve (AUC).