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. 2009 Mar 16;4(3):e4849. doi: 10.1371/journal.pone.0004849

Figure 5. Upregulation of FOXM1B induces non-random genomic instability.

Figure 5

(A) A schematic flow diagram showing the approach used in this study to systematically ‘trace’ the genomic instability patterns (LOH and CNA) within the genomes of 8 individual nicotine/FOXM1B-transformed clones using SNP microarrays. Levels of LOH (B), CNA (C), FOXM1B mRNA (using isoform-specific qPCR, see Supplemental Fig. S3) (D) and FOXM1 protein (E) in respective cell clones. (F) Levels of LOH and CNA in primary human normal oral keratinocytes expressing either EGFP or FOXM1B (n = 3). *(P<0.05), **(P<0.01) and ***(P<0.001) indicate significant increase over control cells.